हड्डी संबंधी
हड्डी संबंधी in 30 Sekunden
- हड्डी संबंधी means 'bone-related' or 'skeletal' in Hindi.
- It is a formal adjective used in medical and scientific contexts.
- It is invariant, meaning it does not change for gender or number.
- It is essential for discussing health, anatomy, and forensics at an advanced level.
The Hindi term हड्डी संबंधी (Haddi Sambandhi) is a compound adjective used to describe anything that pertains to, originates from, or involves the skeletal system or bones. In the linguistic landscape of Hindi, this term bridges the gap between everyday conversational language and formal technical descriptions. While 'Haddi' is the common word for bone, 'Sambandhi' acts as a relational suffix meaning 'related to' or 'pertaining to'. This combination is essential for speakers who need to move beyond simple anatomy into the realms of health, science, and specific physical descriptions. In a medical context, you might hear this when discussing ailments, but in a forensic context, it might describe evidence. The term is versatile because it functions as a precise descriptor, allowing the speaker to categorize a broad range of issues—from a simple fracture to complex osteoporosis—under one thematic umbrella.
- Anatomical Context
- When discussing the human body, this term is used to isolate the skeletal system from the muscular or nervous systems. For example, a doctor might distinguish between a muscular strain and a bone-related (haddi sambandhi) injury.
Understanding the nuance of this word requires looking at its frequency in formal Hindi media. News reports regarding health trends often use it to discuss the rising cases of bone-related diseases among the elderly. It is more formal than saying 'haddi ka' (of the bone) but less esoteric than the Sanskritized 'asthi-vishayak'. This makes it the perfect 'Goldilocks' word for C1 learners—sophisticated enough for academic or professional use, yet accessible enough for daily life. It is frequently employed in compound structures, modifying nouns like 'bimari' (disease), 'operation' (surgery), or 'shodh' (research).
बुढ़ापे में हड्डी संबंधी समस्याओं का खतरा बढ़ जाता है, इसलिए कैल्शियम का सेवन महत्वपूर्ण है। (In old age, the risk of bone-related problems increases, so calcium intake is important.)
Furthermore, the word is indispensable in the field of physical therapy and sports medicine. When an athlete undergoes a diagnostic test, the results might be categorized as 'haddi sambandhi' to indicate that the core structural integrity of the limb is compromised rather than just the soft tissue. This distinction is vital for accurate communication in high-stakes environments. The term also appears in legal and forensic Hindi, where skeletal remains are analyzed. A report might mention 'haddi sambandhi vishleshan' (bone-related analysis) to determine the age or cause of death of a subject. By mastering this term, a learner gains the ability to navigate these specialized domains with confidence and clarity.
वैज्ञानिकों ने प्राचीन गुफा में हड्डी संबंधी अवशेषों की खोज की है। (Scientists have discovered bone-related remains in an ancient cave.)
- Medical Classification
- In hospital registries, patients with fractures or arthritis are often grouped under 'haddi sambandhi rog' (bone-related diseases) for administrative purposes.
Finally, the term is used metaphorically in some advanced literary contexts to describe the 'skeleton' or 'framework' of an idea, though this is less common than its physical application. However, for a C1 learner, the primary focus remains its utility in technical, medical, and descriptive non-fiction prose. It signifies a level of education and precision that marks the transition from intermediate fluency to advanced proficiency. Whether you are reading a health blog, a medical journal, or a news article about nutrition, 'haddi sambandhi' will be your key to unlocking the structural details of the discussion.
Using हड्डी संबंधी correctly requires an understanding of how Hindi adjectives modify nouns. Unlike English, where 'bone-related' might sometimes be replaced by a noun adjunct like 'bone disease', in Hindi, the adjective-noun relationship is very explicit. 'Haddi sambandhi' always precedes the noun it modifies. It does not change based on gender or number because it ends in 'i' (sambandhi), which remains stable as an adjectival suffix derived from the Sanskrit 'sambandhin'. This stability makes it easier to use than some other Hindi adjectives that must agree with the noun's gender.
- Grammar Rule
- The term functions as an invariant adjective. Whether modifying a masculine noun like 'rog' (disease) or a feminine noun like 'bimari' (illness), it stays 'हड्डी संबंधी'.
In professional writing, you will often see this term paired with 'vicar' (disorder), 'shalyachikitsa' (surgery), and 'parikshan' (test). For instance, if you are writing a report on public health, you might write: 'ग्रामीण क्षेत्रों में हड्डी संबंधी जागरूकता की कमी है' (There is a lack of bone-related awareness in rural areas). Here, the term acts as a qualifier that narrows the scope of 'awareness'. It is not just general health awareness, but specifically skeletal health. This precision is what characterizes C1 level usage.
डॉक्टर ने उसे हड्डी संबंधी व्यायाम करने की सलाह दी। (The doctor advised him to do bone-related exercises.)
Another common usage is in the negative or comparative sense. You might say that a certain symptom is 'not bone-related'. In Hindi, this would be 'यह हड्डी संबंधी समस्या नहीं है' (This is not a bone-related problem). This is a common phrase used by medical professionals during differential diagnosis. By excluding skeletal causes, they can narrow down the potential issues to muscular or neurological ones. For a student, practicing these exclusionary sentences is a great way to master the term's application in logical reasoning.
क्या यह दर्द हड्डी संबंधी है या केवल मांसपेशियों का खिंचाव? (Is this pain bone-related or just a muscle strain?)
- Syntactic Placement
- In Hindi syntax, the adjective 'हड्डी संबंधी' usually sits between the subject and the main noun of the predicate, or directly before the object it qualifies.
Finally, consider its use in research. In a sentence like 'हड्डी संबंधी घनत्व' (bone-related density), it functions as a technical descriptor for bone mineral density (BMD). This shows how the word is used in quantitative and qualitative analysis. When you use this term, you are signaling to your audience that you are discussing the structural mechanics of the body. It is a powerful tool for anyone looking to discuss biology, medicine, or even archeology in Hindi.
To truly master हड्डी संबंधी, one must look at the specific environments where it is naturally spoken and written. The most frequent location is the 'Aspatal' (Hospital). In the Orthopedic department, which in Hindi is often referred to as the 'Haddi Vibhag', the term 'haddi संबंधी' is the standard way to describe the nature of a patient's complaints. You will see it on signage, on medical forms, and in the speech of doctors explaining a diagnosis to a family. It provides a formal layer that 'haddi ka' lacks, making the conversation feel more professional and serious.
- Media and Journalism
- Health segments on news channels like Aaj Tak or NDTV India frequently use this term when reporting on vitamin D deficiencies or the impact of sedentary lifestyles on the skeletal health of the urban population.
In the educational sector, particularly in biology textbooks used for the CBSE or ICSE boards in India, 'haddi संबंधी' is used to describe the skeletal system's functions. Students learn about 'haddi संबंधी संरचना' (bone-related structure) and how it supports the body. If you are watching an educational YouTube channel in Hindi about human anatomy, the narrator will almost certainly use this term to describe the various parts of the skeleton. It is a fundamental part of the academic vocabulary for any science student in a Hindi-medium school.
आज के समाचार में हड्डी संबंधी रोगों के उपचार के नए तरीकों पर चर्चा हुई। (In today's news, there was a discussion on new methods of treating bone-related diseases.)
Another interesting place to hear this word is in the fitness industry. Modern gyms in India often have trainers who are well-versed in anatomical terms. They might warn a client about 'haddi संबंधी चोट' (bone-related injury) if their form is incorrect during a heavy lift. This usage shows the word's migration from strictly medical settings into the broader wellness culture. It indicates a more sophisticated understanding of fitness that goes beyond just 'muscles'.
जिम ट्रेनर ने हड्डी संबंधी सुरक्षा के लिए सही तकनीक पर जोर दिया। (The gym trainer emphasized correct technique for bone-related safety.)
- Government Health Campaigns
- Public health posters in clinics often list 'हड्डी संबंधी विकार' (bone-related disorders) as a symptom of malnutrition or aging, encouraging people to get regular checkups.
Lastly, you might encounter this word in literature, particularly in detective or historical fiction. A forensic expert in a novel might describe 'haddi संबंधी साक्ष्य' (bone-related evidence) to solve a crime. This demonstrates the word's ability to create a mood of clinical precision and intellectual depth. By recognizing 'haddi संबंधी' in these diverse contexts, a learner can appreciate how Hindi balances its colloquial roots with formal requirements, providing a rich tapestry of expression for advanced speakers.
One of the most frequent errors learners make with हड्डी संबंधी is confusing it with simpler possessive forms like 'हड्डी का' (haddi ka). While 'haddi ka' literally means 'of the bone', it is often too informal or structurally imprecise for C1-level discourse. For example, 'haddi ka rog' sounds a bit like 'bone's disease', whereas 'haddi संबंधी रोग' sounds like 'bone-related disease'. The latter is the standard medical phrasing. Using the simpler version in a formal presentation might make the speaker sound less professional than they intend.
- Mistake 1: Over-simplification
- Using 'हड्डी का' (Haddi ka) in a formal medical report instead of 'हड्डी संबंधी' (Haddi Sambandhi).
Another common mistake is incorrect word order. Because English speakers are used to 'bone-related', they might try to translate the 'related' part separately or place it after the noun. In Hindi, the entire compound 'हड्डी संबंधी' acts as a single unit that must precede the noun. Saying 'रोग हड्डी संबंधी' is grammatically incorrect in standard prose unless it is part of a very specific poetic or emphatic structure. Always keep the adjective before the noun: 'हड्डी संबंधी समस्या' (bone-related problem).
गलत: वह रोग हड्डी संबंधी है। (Wrong: That disease is bone-related - in this specific word order). सही: वह हड्डी संबंधी रोग है। (Correct: That is a bone-related disease.)
A third mistake is using 'हड्डी संबंधी' when 'अस्थि संबंधी' (asthi sambandhi) would be more appropriate for highly formal or Sanskritized contexts. 'Asthi' is the formal Sanskrit word for bone. While 'haddi संबंधी' is perfect for C1 daily professional life, a PhD thesis on osteology would likely use 'asthi'. Conversely, using 'asthi' in a casual conversation might sound overly pompous. The key is to match the 'weight' of the first word (haddi vs. asthi) with the context of the conversation.
सावधानी: बहुत अधिक औपचारिक लेखों में 'अस्थि संबंधी' का प्रयोग करें, लेकिन सामान्य चर्चा में हड्डी संबंधी ही सबसे अच्छा है। (Caution: Use 'asthi sambandhi' in very formal writings, but 'haddi sambandhi' is best for general discussion.)
- Mistake 2: Gender Agreement
- Some learners try to change 'sambandhi' to 'sambandhini' for feminine nouns. While this exists in pure Sanskrit, in modern Hindi, 'sambandhi' is used for all genders.
Finally, avoid using the term too broadly. It specifically refers to bones. Do not use it for joint issues (which are 'jod sambandhi') or muscle issues ('manspeshi sambandhi') unless the bone itself is involved. Precision is the hallmark of an advanced speaker, and misusing these categories can lead to confusion in a medical or scientific dialogue. By being mindful of these distinctions, you will ensure your Hindi is both accurate and sophisticated.
To expand your vocabulary, it is helpful to compare हड्डी संबंधी with its synonyms and related terms. The most direct formal alternative is अस्थि-विषयक (Asthi-vishayak). This term uses the Sanskrit root 'asthi' and the suffix 'vishayak' (pertaining to the subject of). This is the highest register of the word, found in medical textbooks and formal academic papers. If you are reading a high-level scientific journal, this is the word you will see.
- अस्थि-विषयक (Asthi-vishayak)
- Register: Very Formal/Academic. Example: 'अस्थि-विषयक शोध' (Osteological research). Use this for formal documents.
- कंकाल संबंधी (Kankaal sambandhi)
- Register: Scientific/Forensic. Meaning: Skeletal-related. Example: 'कंकाल संबंधी संरचना' (Skeletal structure). Use this when referring to the entire frame rather than individual bones.
On the other hand, for more casual or specific contexts, you might use हड्डियों का (Haddiyon ka). This is the plural possessive and is commonly used in everyday speech. For example, 'हड्डियों का डॉक्टर' (Doctor of bones) is the colloquial way to say 'Orthopedist'. While 'हड्डी संबंधी विशेषज्ञ' is more formal, 'haddiyon ka doctor' is what you would say to a friend or family member. Knowing when to switch between these registers is a key skill at the C1 level.
तुलना: हड्डी संबंधी (Formal/General) vs. हड्डियों का (Casual/Specific).
There is also the term अस्थि-मज्जा संबंधी (Asthi-majja sambandhi), which specifically refers to the bone marrow. This is a very niche term used in hematology or oncology. As a C1 learner, being able to distinguish between 'haddi' (bone) and 'asthi-majja' (bone marrow) shows a high level of technical proficiency. Similarly, जोड़ों संबंधी (Jodon sambandhi) refers to joints. Since bone and joint issues are often linked, these words frequently appear together in medical literature, such as 'हड्डी और जोड़ों संबंधी विकार' (Bone and joint-related disorders).
मरीज को हड्डी संबंधी और जोड़ों संबंधी दोनों तरह की परेशानियां थीं। (The patient had both bone-related and joint-related problems.)
- Related Terms Table
-
- माँसपेशी संबंधी (Manspeshi sambandhi): Muscular-related.
- नस संबंधी (Nas sambandhi): Nerve/Vein-related.
- ढांचागत (Dhanchagat): Structural (can be used for skeleton).
By mastering these alternatives, you can tailor your speech to your audience. Whether you are talking to a neighbor about their back pain using 'haddiyon ka dard' or presenting a case study using 'haddi संबंधी विकार', your choice of words will reflect your deep understanding of Hindi's stylistic nuances. This versatility is what separates an advanced learner from an intermediate one.
Aussprachehilfe
Beispiele nach Niveau
यह हड्डी है।
This is a bone.
Basic subject-predicate sentence.
कुत्ते को हड्डी पसंद है।
The dog likes the bone.
Use of 'ko' with 'pasand'.
मेरी हड्डी मजबूत है।
My bone is strong.
Feminine noun 'haddi' with feminine adjective 'mazboot'.
यहाँ एक हड्डी है।
There is a bone here.
Use of 'yahan' for 'here'.
वह हड्डी सफेद है।
That bone is white.
Adjective 'safed' modifying 'haddi'.
क्या यह तुम्हारी हड्डी है?
Is this your bone?
Interrogative sentence.
हड्डी मत तोड़ो।
Don't break the bone.
Imperative sentence with 'mat'.
यह छोटी हड्डी है।
This is a small bone.
Adjective 'choti' modifying 'haddi'.
उसे हड्डी संबंधी समस्या है।
He has a bone-related problem.
Use of 'sambandhi' as an adjective.
दूध हड्डी संबंधी स्वास्थ्य के लिए अच्छा है।
Milk is good for bone-related health.
Compound adjective 'haddi sambandhi'.
क्या यह हड्डी संबंधी दर्द है?
Is this a bone-related pain?
Interrogative with 'sambandhi'.
डॉक्टर हड्डी संबंधी रोगों का इलाज करते हैं।
Doctors treat bone-related diseases.
Plural noun 'rogon' with 'sambandhi'.
हड्डी संबंधी कमजोरी बुरी होती है।
Bone-related weakness is bad.
Feminine noun 'kamzori'.
वह हड्डी संबंधी अस्पताल गया।
He went to a bone-related hospital.
Adjective modifying 'aspatal'.
हड्डी संबंधी जांच जरूरी है।
A bone-related checkup is necessary.
Adjective modifying 'jaanch'.
उसे हड्डी संबंधी कोई चोट नहीं है।
He doesn't have any bone-related injury.
Negative sentence.
हड्डी संबंधी ऑपरेशन सफल रहा।
The bone-related operation was successful.
Adjective modifying 'operation'.
विटामिन डी हड्डी संबंधी मजबूती बढ़ाता है।
Vitamin D increases bone-related strength.
Abstract noun 'mazbooti'.
उसे बचपन से ही हड्डी संबंधी विकार हैं।
He has had bone-related disorders since childhood.
Plural noun 'vikar'.
हड्डी संबंधी विज्ञान बहुत रोचक है।
Bone-related science is very interesting.
Noun 'vigyan'.
क्या आपने हड्डी संबंधी क्लिनिक देखा है?
Have you seen the bone-related clinic?
Perfect tense 'dekha hai'.
हड्डी संबंधी सुरक्षा के लिए हेलमेट पहनें।
Wear a helmet for bone-related safety.
Imperative 'pahnen'.
यह दवा हड्डी संबंधी सूजन को कम करती है।
This medicine reduces bone-related inflammation.
Present simple 'kam karti hai'.
हड्डी संबंधी ढांचे को समझना जरूरी है।
It is necessary to understand the bone-related structure.
Infinitive 'samajhna'.
वृद्धावस्था में हड्डी संबंधी घनत्व कम हो जाता है।
In old age, bone-related density decreases.
Technical term 'ghanatva'.
खिलाड़ी अक्सर हड्डी संबंधी चोटों का सामना करते हैं।
Athletes often face bone-related injuries.
Verb phrase 'samna karte hain'.
हड्डी संबंधी रोगों के लिए कैल्शियम युक्त आहार लें।
Take a calcium-rich diet for bone-related diseases.
Compound 'calcium-yukt'.
वैज्ञानिक हड्डी संबंधी पुनर्जनन पर शोध कर रहे हैं।
Scientists are researching bone-related regeneration.
Continuous tense 'kar rahe hain'.
यह अस्पताल हड्डी संबंधी जटिलताओं के लिए प्रसिद्ध है।
This hospital is famous for bone-related complications.
Noun 'jatiltayon'.
हड्डी संबंधी स्वास्थ्य को नजरअंदाज न करें।
Do not ignore bone-related health.
Verb 'nazarandaz karna'.
योग हड्डी संबंधी लचीलेपन में मदद करता है।
Yoga helps in bone-related flexibility.
Noun 'lachilepan'.
हड्डी संबंधी एक्स-रे से फ्रैक्चर का पता चला।
The bone-related X-ray revealed a fracture.
Postposition 'se' indicating source.
हड्डी संबंधी विकृति के कारण उसकी चाल बदल गई।
His gait changed due to a bone-related deformity.
Formal noun 'vikriti'.
हड्डी संबंधी ऊतकों का सूक्ष्म विश्लेषण किया गया।
A microscopic analysis of bone-related tissues was conducted.
Passive construction 'kiya gaya'.
यह शोध हड्डी संबंधी मेटाबॉलिज्म पर केंद्रित है।
This research is focused on bone-related metabolism.
Technical loanword 'metabolism'.
हड्डी संबंधी संक्रमण को रोकने के लिए एंटीबायोटिक्स दिए गए।
Antibiotics were given to prevent bone-related infection.
Noun 'sankraman'.
हड्डी संबंधी कैंसर का शीघ्र पता लगाना चुनौतीपूर्ण है।
Early detection of bone-related cancer is challenging.
Gerund 'pata lagana'.
हड्डी संबंधी शल्य चिकित्सा में नई तकनीकें आई हैं।
New techniques have emerged in bone-related surgery.
Formal term 'shalya chikitsa'.
हड्डी संबंधी विकास में आनुवंशिकी की भूमिका होती है।
Genetics plays a role in bone-related development.
Formal noun 'anuvanshiki'.
हड्डी संबंधी अवशेषों से प्राचीन सभ्यता का पता चला।
The ancient civilization was discovered through bone-related remains.
Noun 'avsheshon'.
हड्डी संबंधी सूक्ष्म-संरचना में परिवर्तन उम्र के साथ अपरिहार्य हैं।
Changes in bone-related micro-structure are inevitable with age.
Complex adjective 'apariharya'.
हड्डी संबंधी विकारों का मनोवैज्ञानिक प्रभाव भी गहरा हो सकता है।
The psychological impact of bone-related disorders can also be profound.
Adjective 'manovaigyanik'.
हड्डी संबंधी खनिजीकरण की प्रक्रिया अत्यंत जटिल है।
The process of bone-related mineralization is extremely complex.
Technical term 'khanijikaran'.
हड्डी संबंधी चिकित्सा के क्षेत्र में भारत ने बहुत प्रगति की है।
India has made much progress in the field of bone-related medicine.
Noun 'pragati'.
हड्डी संबंधी बायोमैकेनिक्स का अध्ययन खेल प्रदर्शन को बेहतर बनाता है।
The study of bone-related biomechanics improves sports performance.
Technical term 'biomechanics'.
हड्डी संबंधी विकारों की रोकथाम के लिए व्यापक जन-जागरूकता आवश्यक है।
Extensive public awareness is essential for the prevention of bone-related disorders.
Adjective 'vyapak'.
हड्डी संबंधी प्रत्यारोपण के बाद पुनर्वास की प्रक्रिया लंबी हो सकती है।
The rehabilitation process after a bone-related transplant can be long.
Noun 'pratyaropan'.
हड्डी संबंधी विकारों के निदान हेतु उन्नत इमेजिंग तकनीकों का प्रयोग होता है।
Advanced imaging techniques are used for the diagnosis of bone-related disorders.
Formal postposition 'hetu'.
Häufige Kollokationen
Häufige Phrasen
— Awareness about bone health and diseases.
सरकार हड्डी संबंधी जागरूकता बढ़ा रही है।
— The act of taking care of one's bones.
बुढ़ापे में हड्डी संबंधी देखभाल जरूरी है।
— Abnormalities or disorders in the bones.
हड्डी संबंधी विकार अनुवांशिक हो सकते हैं।
— Medical tests focused on the bones (like X-rays).
नियमित हड्डी संबंधी जांच करानी चाहिए।
— A specialized hospital for orthopedic issues.
यह शहर का सबसे अच्छा हड्डी संबंधी अस्पताल है।
— Pain specifically originating from the bones.
उसे रात में हड्डी संबंधी दर्द होता है।
— The strength and durability of the bones.
व्यायाम से हड्डी संबंधी मजबूती बढ़ती है।
— The anatomical arrangement of bones.
पक्षी की हड्डी संबंधी संरचना हल्की होती है।
— Finding a cure or fix for bone problems.
डॉक्टर ने मेरी हड्डी संबंधी समस्या का समाधान निकाला।
Redewendungen & Ausdrücke
— Something that has become a deep-rooted part of one's being (literally 'entering the bones').
आलस उसकी हड्डियों में समा गया है।
Informal/Literary— To beat someone very severely (literally 'to make bones and ribs one').
पुलिस ने चोर की हड्डी पसली एक कर दी।
Colloquial— An unwanted third person or an obstacle (literally 'a bone in the kebab').
हम फिल्म देखने जा रहे थे, लेकिन वह कबाब में हड्डी बन गया।
Informal— Extremely thin or emaciated person (literally 'a skeleton of bones').
बीमारी के बाद वह हड्डी का ढांचा रह गया है।
Descriptive/Informal— Something worthless or a person with no substance.
उससे मदद मांगना सूखी हड्डी चबाने जैसा है।
Metaphorical— Back-breaking or extremely hard work.
उसने परीक्षा के लिए हड्डी तोड़ मेहनत की।
Idiomatic— An experienced or tough old person.
वह पुरानी हड्डी है, इतनी आसानी से हार नहीं मानेगा।
Informal— To work until exhaustion or to suffer extreme cold.
इस ठंड ने तो हड्डियां गला दीं।
Colloquial— To show one's true strength or to be very thin.
वह इतना कमजोर है कि उसकी हड्डियां दिख रही हैं।
DescriptiveSummary
The term 'हड्डी संबंधी' is an indispensable C1-level adjective for anyone needing to discuss the skeletal system with precision. For example, 'हड्डी संबंधी रोग' (bone-related disease) is the standard professional way to categorize orthopedic issues.
- हड्डी संबंधी means 'bone-related' or 'skeletal' in Hindi.
- It is a formal adjective used in medical and scientific contexts.
- It is invariant, meaning it does not change for gender or number.
- It is essential for discussing health, anatomy, and forensics at an advanced level.
Verwandte Inhalte
Mehr health Wörter
आंबुलेंस
C1Ein speziell ausgestattetes Fahrzeug, um kranke oder verletzte Personen zu Krankenhäusern zu transportieren.
आहार संबंधी
C1Bezieht sich auf die Ernährung oder Diät.
आहार विशेषज्ञ
B1A person who is an expert on diet and nutrition.
आहार योजना
B1A plan for what to eat; diet plan.
आईसीयू
B1Intensive Care Unit, a specialized hospital ward.
आकस्मिक
B1Sudden, accidental, emergency.
आँखों का डॉक्टर
A2Ein Augenarzt; ein Facharzt für Augenheilkunde.
आनुवंशिक इंजीनियरिंग
C1The deliberate modification of the characteristics of an organism by manipulating its genetic material.
आनुवंशिक परामर्श
C1Ein Prozess der Beratung für Einzelpersonen oder Familien, die von genetischen Störungen betroffen oder gefährdet sind.
आनुवंशिक उत्परिवर्तन
C1Eine dauerhafte Veränderung der DNA-Sequenz, aus der ein Gen besteht.