infested (adjective)
When a place or area is infested, it is filled with a large number of unwanted creatures, especially insects or animals. It often implies a problem that is difficult to get rid of.
Think of 'In-Fests'. The pests are 'In' the house and they are having a 'Fest' (festival/party) that you weren't invited...
The room was infested of ants. → The room was infested with ants.
He is infested with a virus. → He is infected with a virus.
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